CysQuant is a new method for accurately measuring the oxidation levels of cysteine residues in proteins, which is crucial for understanding protein function in redox regulation. It utilizes isotopologues of iodoacetamide to label differentially reduced and reversibly oxidized cysteines, analyzed through data-dependent acquisition (DDA) or data-independent acquisition mass spectrometry (DIA-MS).
Plant PTM Viewer is a centralized resource for plant post-translational modifications (PTMs) intuitive for wet- and dry-lab scientists.
Plant PTM Viewer provides innovative tools to analyze the potential role of PTMs for specific proteins or in a broader systems biology context.
Metacaspases (MCs) are a family of cysteine proteases discovered due to their structural similarity to animal caspases. Unlike caspases, however, metacaspases are found exclusively in non-metazoan organisms and have a unique ability to cleave proteins at lysine and arginine residues. MCs are categorized into three types based on their domain architecture: Type-I and Type-II MCs are present in plants, while Type-III MCs are specific to algae.
Why a focus on retrograde signaling in plants? Biological systems must respond rapidly to both external and internal stimuli to maintain homeostasis, and repair damage. To allow rapid responses, biology often relies on post-translational modifications of specific proteins to effect changes in activity, function, localization, or stability of pre-existing proteins. Several studies have shown that chloroplast and mitochondrial functions are direct target of stresses, from changes in the proteome, altering organellar abundance or modification of large-scale changes in the transcriptome.
The EU's Marie Sklodowska-Curie Actions provide postdoctoral fellowships to talented researchers. These MSCA fellowships provide an opportunity for young scientists to conduct research in different countries, gain expertise, and advance their professional pursuits. Following the addition of four Marie Curie fellows this year, VIB is now welcoming three more.
